Burns makes it 1-0 in Game 4 for the Sharks!
the golden tweets of gabriel landeskog
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Mechanism of HIV membrane fusion with a CD4-expressing immune cell:
1. Initial interaction between gp120 and CD4.
2. Conformational change in gp120 allows for secondary interaction with a cell-type specific chemokine, e.g. CCR5.
3. The distal tips of gp41 are inserted in to the cellular membrane.
4. gp41 undergoes significant conformational change; folding in half and forming coiled-coils. This process pulls the viral and cellular membranes together, fusing them.
Following fusion, the viral core is released into the cell cytoplasm.